PI3K/AKT信号通路在心肌病中应用的研究进展
Research Advances in the Application of PI3K/AKT Signaling Pathway in Cardiomyopathy
DOI: 10.12677/acm.2024.14112844, PDF,  被引量   
作者: 向仲双：南华大学附属怀化医院，湖南 衡阳；申 强：湖南医药学院总医院，心血管内科，湖南 怀化
关键词: PI3K；AKT；扩张性心肌病；糖尿病心肌病；肥厚性心肌病；其他类型心肌病；PI3K； AKT； Dilated Cardiomyopathy； Diabetic Cardiomyopathy； Hypertrophic Cardiomyopathy； Other Types of Cardiomyopathy Hospital
摘要: 磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B (AKT)通路作为信号通路中的明星通路之一，在各个领域均发挥重要作用，如心血管疾病、肿瘤、内分泌系统疾病及其他全身系统疾病等。研究发现PI3K/AKT信号通路参与细胞的生长、代谢、凋亡及糖脂代谢等途径，有进一步研究表明PI3K/AKT信号通路是影响代谢性心血管疾病发病和进展的重要通路之一。深入探究PI3K/AKT信号通路在心肌病中的作用机制，对心肌病的预防、治疗及预后评估具有一定的临床价值。
Abstract: Phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway, as one of the star signaling pathways, plays an important role in various fields, such as cardiovascular diseases, tumors, endocrine system diseases and other systemic diseases. Studies have found that PI3K/AKT signaling pathway is involved in cell growth, metabolism, apoptosis, glucose and lipid metabolism, and other pathways. Further studies have shown that PI3K/AKT signaling pathway is one of the important pathways affecting the pathogenesis and progression of metabolic cardiovascular diseases. Further exploration of the mechanism of PI3K/AKT signaling pathway in cardiomyopathy has certain clinical value for the prevention, treatment and prognosis evaluation of cardiomyopathy.
文章引用：向仲双, 申强. PI3K/AKT信号通路在心肌病中应用的研究进展[J]. 临床医学进展, 2024, 14(11): 51-56. https://doi.org/10.12677/acm.2024.14112844

参考文献

[1] Elliott, P., Andersson, B., Arbustini, E., Bilinska, Z., Cecchi, F., Charron, P., et al. (2007) Classification of the Cardiomyopathies: A Position Statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. European Heart Journal, 29, 270-276. [Google Scholar] [CrossRef] [PubMed]
[2] Semsarian, C., Ingles, J., Maron, M.S. and Maron, B.J. (2015) New Perspectives on the Prevalence of Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 65, 1249-1254. [Google Scholar] [CrossRef] [PubMed]
[3] Maron, M.S., Hellawell, J.L., Lucove, J.C., Farzaneh-Far, R. and Olivotto, I. (2016) Occurrence of Clinically Diagnosed Hypertrophic Cardiomyopathy in the United States. The American Journal of Cardiology, 117, 1651-1654. [Google Scholar] [CrossRef] [PubMed]
[4] Weintraub, R.G., Semsarian, C. and Macdonald, P. (2017) Dilated Cardiomyopathy. The Lancet, 390, 400-414. [Google Scholar] [CrossRef] [PubMed]
[5] Brieler, J., Breeden, M.A. and Tucker, J. (2017) Cardiomyopathy: An Overview. American Family Physician, 96, 640-646.
[6] Yamada, T. and Nomura, S. (2021) Recent Findings Related to Cardiomyopathy and Genetics. International Journal of Molecular Sciences, 22, Article No. 12522. [Google Scholar] [CrossRef] [PubMed]
[7] 赵林丽, 吕云鹏, 唐青, 等. PI3K/AKT/mTOR信号通路在心血管疾病中的作用及其药物靶向治疗[J]. 中国实用医药, 2021, 16(4): 151-155.
[8] Ghafouri-Fard, S., Khanbabapour Sasi, A., Hussen, B.M., Shoorei, H., Siddiq, A., Taheri, M., et al. (2022) Interplay between PI3K/AKT Pathway and Heart Disorders. Molecular Biology Reports, 49, 9767-9781. [Google Scholar] [CrossRef] [PubMed]
[9] Wang, J., Hu, K., Cai, X., Yang, B., He, Q., Wang, J., et al. (2022) Targeting PI3K/AKT Signaling for Treatment of Idiopathic Pulmonary Fibrosis. Acta Pharmaceutica Sinica B, 12, 18-32. [Google Scholar] [CrossRef] [PubMed]
[10] Ghafouri-Fard, S., Khanbabapour Sasi, A., Hussen, B.M., Shoorei, H., Siddiq, A., Taheri, M., et al. (2022) Interplay between PI3K/AKT Pathway and Heart Disorders. Molecular Biology Reports, 49, 9767-9781. [Google Scholar] [CrossRef] [PubMed]
[11] Engelman, J.A., Luo, J. and Cantley, L.C. (2006) The Evolution of Phosphatidylinositol 3-Kinases as Regulators of Growth and Metabolism. Nature Reviews Genetics, 7, 606-619. [Google Scholar] [CrossRef] [PubMed]
[12] Durrant, T.N. and Hers, I. (2020) PI3K Inhibitors in Thrombosis and Cardiovascular Disease. Clinical and Translational Medicine, 9, e8. [Google Scholar] [CrossRef] [PubMed]
[13] Fayard, E., Xue, G., Parcellier, A., Bozulic, L. and Hemmings, B.A. (2010) Protein Kinase B (PKB/AKT), a Key Mediator of the PI3K Signaling Pathway. In: Rommel, C., Vanhaesebroeck, B. and Vogt, P.K., Eds., Phosphoinositide 3-Kinase in Health and Disease, Springer, 31-56. [Google Scholar] [CrossRef] [PubMed]
[14] Hanada, M., Feng, J. and Hemmings, B.A. (2004) Structure, Regulation and Function of PKB/AKT—A Major Therapeutic Target. Biochimica et Biophysica Acta (BBA)—Proteins and Proteomics, 1697, 3-16. [Google Scholar] [CrossRef] [PubMed]
[15] 郭一澎, 安丽萍. PI3K/AKT/mTOR信号通路与心血管疾病的关系[J]. 齐齐哈尔医学院学报, 2023, 44(20): 1932-1936.
[16] 李玉华, 赵敏. PI3K/AKT信号通路调控心肌细胞凋亡的研究进展[J]. 疑难病杂志, 2019, 18(11): 1169-1173.
[17] 陈伟佳, 白烨升, 祁玉营, 等. 参丹方通过PI3K/AKT信号通路改善扩张型心肌病大鼠心肌细胞凋亡的研究[J]. 中国临床药理学杂志, 2023, 39(21): 3116-3120.
[18] Dong, W., Guan, F., Zhang, X., Gao, S., Liu, N., Chen, W., et al. (2018) Dhcr24 Activates the PI3K/AKT/HKII Pathway and Protects against Dilated Cardiomyopathy in Mice. Animal Models and Experimental Medicine, 1, 40-52. [Google Scholar] [CrossRef] [PubMed]
[19] Zhu, M., Chen, Y., Cheng, L., et al. (2022) Calsyntenin-1 Promotes Doxorubicin-Induced Dilated Cardiomyopathy in Rats. Cardiovascular Drugs and Therapy, 38, 237-252.
[20] Zhang, C., Huang, Y., Lu, J., Lin, J., Ge, Z. and Huang, H. (2018) Retracted: Upregulated MicroRNA‐132 Rescues Cardiac Fibrosis and Restores Cardiocyte Proliferation in Dilated Cardiomyopathy through the Phosphatase and Tensin Homolog-Mediated PI3K/AKT Signal Transduction Pathway. Journal of Cellular Biochemistry, 120, 1232-1244. [Google Scholar] [CrossRef] [PubMed]
[21] 苏笑宇, 朱禹奇, 段默涵, 等. 黄芪甲苷通过PI3K/AKT信号通路改善2型糖尿病大鼠心脏功能的研究进展[J]. 名医, 2023(20): 36-38.
[22] Miki, T., Yuda, S., Kouzu, H. and Miura, T. (2012) Diabetic Cardiomyopathy: Pathophysiology and Clinical Features. Heart Failure Reviews, 18, 149-166. [Google Scholar] [CrossRef] [PubMed]
[23] Ren, B., Zhang, Y., Liu, S., Cheng, X., Yang, X., Cui, X., et al. (2020) Curcumin Alleviates Oxidative Stress and Inhibits Apoptosis in Diabetic Cardiomyopathy via Sirt1‐Foxo1 and PI3K-AKT Signalling Pathways. Journal of Cellular and Molecular Medicine, 24, 12355-12367. [Google Scholar] [CrossRef] [PubMed]
[24] Zhong, L., Li, J., Yu, J., Cao, X., Du, J., Liang, L., et al. (2024) Anemarrhena Asphodeloides Bunge Total Saponins Ameliorate Diabetic Cardiomyopathy by Modifying the PI3K/AKT/HIF-1α Pathway to Restore Glycolytic Metabolism. Journal of Ethnopharmacology, 319, Article ID: 117250. [Google Scholar] [CrossRef] [PubMed]
[25] Han, Z., Zhao, D., Han, M., Zhang, R. and Hao, Y. (2022) Knockdown of MIR-372-3p Inhibits the Development of Diabetic Cardiomyopathy by Accelerating Angiogenesis via Activating the PI3K/AKT/mTOR/HIF-1α Signaling Pathway and Suppressing Oxidative Stress. Oxidative Medicine and Cellular Longevity, 2022, Article ID: 4342755. [Google Scholar] [CrossRef] [PubMed]
[26] Yang, X., Li, X., Lin, Q. and Xu, Q. (2019) Up-Regulation of Microrna-203 Inhibits Myocardial Fibrosis and Oxidative Stress in Mice with Diabetic Cardiomyopathy through the Inhibition of PI3K/AKT Signaling Pathway via PIK3CA. Gene, 715, Article ID: 143995. [Google Scholar] [CrossRef] [PubMed]
[27] Li, D., Guo, Y., Cen, X., Qiu, H., Chen, S., Zeng, X., et al. (2021) Lupeol Protects against Cardiac Hypertrophy via TLR4-PI3K-AKT-NF-κB Pathways. Acta Pharmacologica Sinica, 43, 1989-2002. [Google Scholar] [CrossRef] [PubMed]
[28] Liu, M., Luo, G., Dong, L., Mazhar, M., Wang, L., He, W., et al. (2022) Network Pharmacology and in Vitro Experimental Verification Reveal the Mechanism of the Hirudin in Suppressing Myocardial Hypertrophy. Frontiers in Pharmacology, 13, Article ID: 914518. [Google Scholar] [CrossRef] [PubMed]
[29] Qian, W., Yu, D., Zhang, J., Hu, Q., Tang, C., Liu, P., et al. (2018) Wogonin Attenuates Isoprenaline-Induced Myocardial Hypertrophy in Mice by Suppressing the PI3K/AKT Pathway. Frontiers in Pharmacology, 9, Article No. 896. [Google Scholar] [CrossRef] [PubMed]
[30] Jiang, Y., Chen, L., Chao, Z., Chen, T. and Zhou, Y. (2022) Ferroptosis Related Genes in Ischemic and Idiopathic Cardiomyopathy: Screening for Potential Pharmacological Targets. Frontiers in Cell and Developmental Biology, 10, Article ID: 817819. [Google Scholar] [CrossRef] [PubMed]
[31] Mao, W., Iwai, C., Liu, J., Sheu, S., Fu, M. and Liang, C. (2008) Darbepoetin Alfa Exerts a Cardioprotective Effect in Autoimmune Cardiomyopathy via Reduction of ER Stress and Activation of the PI3K/AKT and STAT3 Pathways. Journal of Molecular and Cellular Cardiology, 45, 250-260. [Google Scholar] [CrossRef] [PubMed]
[32] Zhou, S., Yin, X., Jin, J., Tan, Y., Conklin, D.J., Xin, Y., et al. (2017) Intermittent Hypoxia-Induced Cardiomyopathy and Its Prevention by Nrf2 and Metallothionein. Free Radical Biology and Medicine, 112, 224-239. [Google Scholar] [CrossRef] [PubMed]

为你推荐