溃疡性结肠炎伴坏疽性脓皮病1例
A Case of Ulcerative Colitis with Pyoderma Gangrenosa
DOI: 10.12677/acm.2024.14112849, PDF,   
作者: 杨凯丽：西安医学院研究生处，陕西 西安；陕西省人民医院消化内一科，陕西 西安；张 雨, 刘贵生*：陕西省人民医院消化内一科，陕西 西安
关键词: 溃疡性结肠炎；坏疽性脓皮病；炎症性肠病并发症；免疫制剂；Ulcerative Colitis； Pyoderma Gangrenosa； Inflammatory Bowel Disease Complications； Immunological Preparation
摘要: 坏疽性脓皮病(PG)，一种罕见的、非感染性的中性粒细胞性皮肤病，常伴有其他全身疾病，其特征是疼痛性溃疡、边界模糊和外周红斑，其在溃疡性结肠炎(UC)患者中较为少见，是肠外表现的一种。本文将报道一例溃疡性结肠炎合并坏疽性脓皮病诊疗过程并进行文献复习，旨在提高临床医生对该疾病的认识以减少误诊、误治。
Abstract: Pyoderma gangrenosa (PG), a rare, non-infectious neutrophil skin disease often associated with other systemic diseases, characterized by painful ulcers, blurred boundaries, and peripheral erythema, is less common in patients with ulcerative colitis (UC) and is one of the extrenteral manifestations. This article reports a case of ulcerative colitis complicated with pyoderma gangrenosa and reviews the literature, aiming to improve the clinician’s understanding of this disease and reduce misdiagnosis and mistreatment.
文章引用：杨凯丽, 张雨, 刘贵生. 溃疡性结肠炎伴坏疽性脓皮病1例[J]. 临床医学进展, 2024, 14(11): 81-86. https://doi.org/10.12677/acm.2024.14112849

参考文献

[1] Segal, J.P., LeBlanc, J. and Hart, A.L. (2021) Ulcerative Colitis: An Update. Clinical Medicine, 21, 135-139. [Google Scholar] [CrossRef] [PubMed]
[2] Khrom, M., Long, M., Dube, S., Robbins, L., Botwin, G.J., Yang, S., et al. (2024) Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease. Gastroenterology, 167, 315-332. [Google Scholar] [CrossRef] [PubMed]
[3] 丁香玉, 李承新. 消化系统疾病的皮肤表现综述[J]. 解放军医学院学报, 2022, 43(1): 106-109.
[4] Maverakis, E., Marzano, A.V., Le, S.T., Callen, J.P., Brüggen, M., Guenova, E., et al. (2020) Pyoderma Gangrenosum. Nature Reviews Disease Primers, 6, Article No. 81. [Google Scholar] [CrossRef] [PubMed]
[5] Plumptre, I., Knabel, D. and Tomecki, K. (2018) Pyoderma Gangrenosum: A Review for the Gastroenterologist. Inflammatory Bowel Diseases, 24, 2510-2517. [Google Scholar] [CrossRef] [PubMed]
[6] Vornehm, N.D., Kelley, S.R. and Ellis, B.J. (2011) Parastomal Small Bowel Evisceration as a Result of Parastomal Pyoderma Gangrenosum in a Patient with Crohn’s Disease. The American Surgeon, 77, E150-E151.
[7] Marzano, A.V., Fanoni, D., Antiga, E., Quaglino, P., Caproni, M., Crosti, C., et al. (2014) Expression of Cytokines, Chemokines and Other Effector Molecules in Two Prototypic Autoinflammatory Skin Diseases, Pyoderma Gangrenosum and Sweet’s Syndrome. Clinical and Experimental Immunology, 178, 48-56.
[8] 杨秋碧, 周晓鸿, 秦帆, 等. 坏疽性脓皮病的发病机制及治疗进展[J]. 皮肤病与性病, 2024, 46(1): 19-23.
[9] Wollina, U. (2007) Pyoderma Gangrenosum—A Review. Orphanet Journal of Rare Diseases, 2, Article No. 19. [Google Scholar] [CrossRef] [PubMed]
[10] Su, W.P.D., Davis, M.D.P., Weenig, R.H., Powell, F.C. and Perry, H.O. (2004) Pyoderma Gangrenosum: Clinicopathologic Correlation and Proposed Diagnostic Criteria. International Journal of Dermatology, 43, 790-800. [Google Scholar] [CrossRef] [PubMed]
[11] Jockenhöfer, F., Wollina, U., Salva, K.A., Benson, S. and Dissemond, J. (2018) The PARACELSUS Score: A Novel Diagnostic Tool for Pyoderma Gangrenosum. British Journal of Dermatology, 180, 615-620. [Google Scholar] [CrossRef] [PubMed]
[12] Haag, C., Hansen, T., Hajar, T., Latour, E., Keller, J., Shinkai, K., et al. (2021) Comparison of Three Diagnostic Frameworks for Pyoderma Gangrenosum. Journal of Investigative Dermatology, 141, 59-63. [Google Scholar] [CrossRef] [PubMed]
[13] Maverakis, E., Marzano, A.V., Le, S.T., Callen, J.P., Brüggen, M., Guenova, E., et al. (2020) Pyoderma Gangrenosum. Nature Reviews Disease Primers, 6, Article No. 81. [Google Scholar] [CrossRef] [PubMed]
[14] Ahronowitz, I., Harp, J. and Shinkai, K. (2012) Etiology and Management of Pyoderma Gangrenosum. American Journal of Clinical Dermatology, 13, 191-211. [Google Scholar] [CrossRef] [PubMed]
[15] Sassolas, B., le Ru, Y., Plantin, P., Lair, G., Dupre, P., Cochard, G., et al. (2000) Pyoderma Gangrenosum with Pathergic Phenomenon in Pregnancy. British Journal of Dermatology, 142, 827-828. [Google Scholar] [CrossRef] [PubMed]
[16] Thomas, K.S., Ormerod, A.D., Craig, F.E., Greenlaw, N., Norrie, J., Mitchell, E., et al. (2016) Clinical Outcomes and Response of Patients Applying Topical Therapy for Pyoderma Gangrenosum: A Prospective Cohort Study. Journal of the American Academy of Dermatology, 75, 940-949. [Google Scholar] [CrossRef] [PubMed]
[17] Patel, F., Fitzmaurice, S., Duong, C., He, Y., Fergus, J., Raychaudhuri, S., et al. (2015) Effective Strategies for the Management of Pyoderma Gangrenosum: A Comprehensive Review. Acta Dermato Venereologica, 95, 525-531. [Google Scholar] [CrossRef] [PubMed]
[18] Gettler, S.L., Rothe, M.J., Grin, C. and Grant-Kels, J.M. (2003) Optimal Treatment of Pyoderma Gangrenosum. American Journal of Clinical Dermatology, 4, 597-608. [Google Scholar] [CrossRef] [PubMed]
[19] Westerdahl, J.S., Nusbaum, K.B., Chung, C.G., Kaffenberger, B.H. and Ortega-Loayza, A.G. (2021) Ustekinumab as Adjuvant Treatment for All Pyoderma Gangrenosum Subtypes. Journal of Dermatological Treatment, 33, 2386-2390. [Google Scholar] [CrossRef] [PubMed]
[20] Gameiro, A., Pereira, N., Cardoso, J.C. and Gonçalo, M. (2015) Pyoderma Gangrenosum: Challenges and Solutions. OncoTargets and Therapy, 8, 285-293. [Google Scholar] [CrossRef] 

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