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Mustada, V.A., De Michelea, S., Huanga, Y.-S., et al. (2006) Differential Effects of n-3 Polyunsaturated Fatty Acids on Metabolic Control and Vascular Reactivity in the Type 2 Diabetic ob/ob Mouse. Metabolism, 55, 1365-1374. https:/doi.org/10.1016/j.metabol.2006.06.007

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• 标题: n-3多不饱和脂肪酸在胰岛素抵抗、肥胖、糖尿病治疗作用的研究进展Research Progress of the Omega-3 Fatty Acids in the Treatment of Insulin Resistance, Obesity, Diabetes

  作者: 于鸿悦, 肖新华, 胡玲

  关键字: n-3多不饱和脂肪酸, 胰岛素抵抗, 肥胖, 糖尿病Omega-3 Fatty Acids, Insulin Resistance, Obesity, Diabetes

  期刊名称: 《Hans Journal of Food and Nutrition Science》, Vol.5 No.4, 2016-11-29

  摘要: 胰岛素抵抗、肥胖、糖尿病等慢性代谢性疾病已经成为严重威胁人类健康的世界性公共卫生问题，它们呈共同免疫-代谢关联状态，在炎症激活、血脂异常和心血管疾病上有协同效应。而n-3多不饱和脂肪酸是一类具有调节代谢和免疫作用的多不饱和脂肪酸，可能会减少促炎细胞因子、改善胰岛素抵抗以及降低血脂水平。本文综述了n-3多不饱和脂肪酸对胰岛素抵抗、肥胖、糖尿病治疗作用的研究进展。 Insulin resistance, obesity, diabetes and other metabolic diseases have become global public health problems, which exert detrimental effect on health worldwide. They share a common im-mune-metabolic link state which have a synergistic effect on the activation of inflammation, dysli-pidemia, and cardiovascular diseases. Omega-3 fatty acids are capable of modulating both meta-bolic and immune process, which may decrease pro-inflammatory cytokines, improve insulin re-sistance, and regulate dyslipidemia. This review aimed to summarize on the effect of the omega-3 fatty acids on the prevention and treatment of insulin resistance, obesity and diabetes.