紫花地丁化学成分和药理活性研究进展
Research Progress of Viola yedoensis Makino
DOI: 10.12677/hjmce.2025.132017, PDF,   
作者: 罗荣美, 马会如, 李 佳*:昆明医科大学药学院暨云南省天然药物药理重点实验室,云南 昆明
关键词: 紫花地丁化学成分药理活性Viola yedoensis Makino Chemical Components Pharmacological Activities
摘要: 紫花地丁是堇菜科植物紫花地丁的干燥全草,作为我国传统医药体系中的重要药用植物,凭借其广泛的生物活性与资源可持续性优势,在民间医疗实践中被广泛应用。该植物具有显著的抗炎、抗菌、抗病毒等多重生物活性,其化学组分涵盖黄酮、生物碱、环烯醚萜、酚酸及多糖等复杂体系,展现出独特的“多组分–多靶点–多通路”作用特征。本文对近年来紫花地丁的化学成分和药理作用予以综述。
Abstract: Viola yedoensis Makino also called Viola philippica Cav, a dried whole herb of the Violaceae family, is a significant medicinal plant in traditional Chinese medicine. Owing to its extensive biological activities and sustainable resource advantages, it has been widely utilized in folk medical practices. This plant exhibits remarkable multi-pharmacological properties, including anti-inflammatory, antibacterial, and antiviral activities. Its chemical composition comprises a complex system of flavonoids, alkaloids, iridoids, phenolic acids, and polysaccharides, demonstrating a unique “multi-component, multi-target, multi-pathway” mechanism of action. This paper reviews the recent advances in the chemical constituents and pharmacological activities of Viola yedoensis Makino.
文章引用:罗荣美, 马会如, 李佳. 紫花地丁化学成分和药理活性研究进展[J]. 药物化学, 2025, 13(2): 157-167. https://doi.org/10.12677/hjmce.2025.132017

参考文献

[1] 杨鹏鹏, 闫福林, 梁一兵, 等. 紫花地丁化学成分的研究[J]. 新乡医学院学报, 2008, 25(2): 185-187.
[2] 国家药典委员会. 中华人民共和国药典(一部) [M]. 北京: 中国医药科技出版社, 2015: 337-338.
[3] 李嘉欣, 杨凤琴, 王好欣, 等. 宁夏、青海产紫花地丁对8种菌株的抑菌作用研究[J]. 宁夏医科大学学报, 2019, 41(1): 49-52.
[4] 张静, 邵永斌, 谷新利, 等. 紫花地丁总黄酮体外抗炎活性研究[J]. 中国畜牧兽医, 2020, 47(4): 1258-1266.
[5] 符佳, 陈加容, 胡樱凡, 等. 紫花地丁提取物对LPS诱导RAW 264.7细胞的体外抗炎作用[J]. 成都大学学报(自然科学版), 2020, 39(2): 143-147.
[6] 崔雪, 郑重飞, 李莹, 等. 紫花地丁化学成分和抗病毒作用的研究进展[J]. 食品与药品, 2020, 22(3): 226-232.
[7] 李静, 王倩, 兰杨, 等. 紫花地丁黄酮体外抗氧化实验[J]. 广州化工, 2017, 45(21): 54-55.
[8] 张芳娟, 张璇, 牛颜冰, 等. 蒲公英和紫花地丁水提物的抗癌活性研究[J]. 西北药学杂志, 2019, 34(6): 759-765.
[9] 李海涛, 杨琳, 章广玲, 等. 紫花地丁煎剂调节小鼠巨噬细胞功能的体内实验研究[J]. 华北煤炭医学院, 2004, 6(5): 553-554.
[10] 陈胡兰, 张沛然, 胡兴. 紫花地丁抗炎及体外抑菌作用活性部位的筛选研究[J]. 成都中医药大学学报, 2008, 31(2): 52-53.
[11] Xie, C., Veitch, N.C., Houghton, P.J. and Simmonds, M.S.J. (2003) Flavone C-Glycosides from Viola yedoensis Makino. Chemical and Pharmaceutical Bulletin, 51, 1204-1207. [Google Scholar] [CrossRef] [PubMed]
[12] Oshima, N., Narukawa, Y., Takeda, T. and Kiuchi, F. (2012) Collagenase Inhibitors from Viola yedoensis. Journal of Natural Medicines, 67, 240-245. [Google Scholar] [CrossRef] [PubMed]
[13] 陈胡兰, 董小萍, 张梅, 等. 紫花地丁化学成分研究[J]. 中草药, 2010, 41(6): 874-877.
[14] 吴强, 高燕萍. 紫花地丁化学成分和药理活性研究概况[J]. 中国民族民间医药, 2017, 26(22): 35-38.
[15] 徐金钟, 曾珊珊, 瞿海斌. 紫花地丁化学成分研究[J]. 中草药, 2010, 41(9): 1423-1425.
[16] Zhou, H., Qin, M., Hong, J., Ni, Y. and Wu, G. (2009) Chemical Constituents of Viola yedoensis. Chinese Journal of Natural Medicines, 7, 290-292. [Google Scholar] [CrossRef
[17] 肖永庆, 毕俊英, 刘晓宏, 等. 地丁化学成分研究[J]. 植物学报, 1987, 29(5): 532-536.
[18] 柳航, 胡巍, 方芸. 紫花地丁乙酸乙酯部位的化学成分研究[J]. 安徽医药, 2015, 19(6): 1068-1071.
[19] Zhou, H.Y., Hong, J.L., Shu, P., Ni, Y.J. and Qin, M.J. (2009) A New Dicoumarin and Anticoagulant Activity from Viola yedoensis Makino. Fitoterapia, 80, 283-285. [Google Scholar] [CrossRef] [PubMed]
[20] Yao, X., Luo, X.-Z. and Xie, C. (2010) Chemical Constituents from Viola yedoensis. Chemistry of Natural Compounds, 46, 809-810. [Google Scholar] [CrossRef
[21] 孙艺方, 杜利利, 周乐, 等. 紫花地丁抗菌活性成分研究[J]. 中国中药杂志, 2011, 36(19): 2666-2671.
[22] 黄霁秋, 杨敬芝, 薛清春, 等. 紫花地丁化学成分研究[J]. 中国中药杂志, 2009, 34(9): 1114-1116.
[23] 李永生, 何希瑞, 杨燕, 等. 紫花地丁化学成分与药理活性研究新进展[J]. 环球中医药, 2013, 6(4): 313-318.
[24] 周驰. 紫花地丁的本草考证及化学成分研究[D]: [硕士学位论文]. 北京中医药大学, 2008.
[25] 姚霞. 中国枸杞属植物不同种质资源的研究及紫花地丁的化学成分研究[D]: [博士学位论文]. 北京: 中国协和医科大学, 2010.
[26] Du, D., Cheng, Z. and Chen, D. (2015) Anti-Complement Sesquiterpenes from Viola yedoensis. Fitoterapia, 101, 73-79. [Google Scholar] [CrossRef] [PubMed]
[27] Takazawa, O., Kogami, K. and Hayashi, K. (1983) New Synthesis of Loliolide, Dehydrololiolide, and 3-Oxoactinidol. Chemistry Letters, 12, 63-64. [Google Scholar] [CrossRef
[28] 陈胡兰. 紫花地丁化学成分及质量控制研究[D]: [博士学位论文]. 成都: 成都中医药大学, 2009.
[29] 崔雪, 郑重飞, 李莹, 等. 紫花地丁全草化学成分研究[J]. 中草药, 2021, 52(4): 917-924.
[30] 陈玉花, 肖德华. 紫花地丁挥发油化学成分分析[J]. 内蒙古民族大学学报(自然科学版), 2008, (1): 22-23, 58.
[31] 刘嘉, 徐润生, 程存归. 两产地紫花地丁挥发油的化学成分研究[J]. 中成药, 2009, 31(10): 1575-1577.
[32] 李媛媛, 毛妍, 梁曾恩妮, 等. 紫花地丁药理作用研究进展[J]. 中国畜牧兽医, 2023, 50(7): 2998-3006.
[33] Wei, T., Guo, J., Hong, A., He, Q., Chen, J., Ren, Z., et al. (2024) Preparation, Characterization, and Immune Activity of Viola philippica Polysaccharide PLGA Nanoparticles. Chemistry & Biodiversity, 22, e202402819. [Google Scholar] [CrossRef] [PubMed]
[34] Sanhueza, L., Melo, R., Montero, R., Maisey, K., Mendoza, L. and Wilkens, M. (2017) Synergistic Interactions between Phenolic Compounds Identified in Grape Pomace Extract with Antibiotics of Different Classes against Staphylococcus Aureus and Escherichia Coli. PLOS ONE, 12, e0172273. [Google Scholar] [CrossRef] [PubMed]
[35] 陈蔚燕. 紫花地丁不同方式提取物抑菌效果研究[J]. 现代农药, 2014, 13(5): 38-40.
[36] 金兰梅, 伍清林, 张越, 等. 紫花地丁对奶牛乳房炎主要病原菌体外抑菌试验[J]. 金陵科技学院学报, 2015, 31(2): 79-84.
[37] 杨佳冰, 丁大旺, 赵金香, 等. 紫花地丁总生物碱抗病毒与抑菌试验[J]. 中兽医医药杂志, 2011, 30(4): 8-10.
[38] 李艳丽, 胡彦武. 紫花地丁抗炎作用及机制研究[J]. 中国实验方剂学杂志, 2012, 18(24): 244-247.
[39] 陈志良, 刘聪, 廖自文, 等. 紫花地丁总黄酮的提取工艺及抗炎作用研究[J]. 中国畜牧兽医, 2024, 51(11): 5051-5063.
[40] Zeng, H., Zhao, B., Zhang, D., Rui, X., Hou, X., Chen, X., et al. (2022) Viola yedoensis Makino Formula Alleviates DNCB-Induced Atopic Dermatitis by Activating JAK2/STAT3 Signaling Pathway and Promoting M2 Macrophages Polarization. Phytomedicine, 103, Article 154228. [Google Scholar] [CrossRef] [PubMed]
[41] 王群, 郑婧. 国医大师张志远临床应用蒲公英、紫花地丁经验总结[J]. 中国民间疗法, 2018, 26(13): 8-9.
[42] 曹捷, 秦艳, 尹成乐, 等. 紫花地丁化学成分及抗氧化活性[J]. 中国实验方剂学杂志, 2013, 19(21): 77-81.
[43] 段建荣, 严贵亮, 杨辉. 响应面法优化紫花地丁总酚酸的提取工艺及其抗氧化活性研究[J]. 山西医科大学学报, 2020, 51(7): 683-688
[44] 顾生玖, 姚志仁, 顾超豪, 等. 基于响应面法优化紫花地丁多酚与黄酮的提取工艺[J]. 食品研究与开发, 2022, 43(9): 88-95.
[45] 褚海清, 王倩, 李佼宁, 等. 紫花地丁中挥发油和黄酮类成分的抗氧化协同作用[J]. 宁夏医科大学学报, 2020, 42(3): 271-274.
[46] 伍小波, 古淑英, 罗先钦, 等. 紫花地丁黄酮类提取物体外抗传染性支气管炎病毒作用研究[J]. 中国兽医学报,2012,32(11): 1694-1697.
[47] Yu, Q., Liu, M., Xiao, H., Wu, S., Qin, X., Lu, Z., et al. (2019) The Inhibitory Activities and Antiviral Mechanism of Viola philippica Aqueous Extracts against Grouper Iridovirus Infection in vitro and in vivo. Journal of Fish Diseases, 42, 859-868. [Google Scholar] [CrossRef] [PubMed]
[48] Wang, Y., Zhang, L., Li, M., Wang, L. and Ma, C. (2018) Lignans, Flavonoids and Coumarins from Viola philippica and Their Α-Glucosidase and HCV Protease Inhibitory Activities. Natural Product Research, 33, 1550-1555. [Google Scholar] [CrossRef] [PubMed]
[49] Yang, Y., Cheng, H., Yan, H., Wang, P., Rong, R., Zhang, Y., et al. (2016) A Cell-Based High-Throughput Protocol to Screen Entry Inhibitors of Highly Pathogenic Viruses with Traditional Chinese Medicines. Journal of Medical Virology, 89, 908-916. [Google Scholar] [CrossRef] [PubMed]
[50] 王玉, 吴中明, 敖弟书, 等. 紫花地丁水浸出物对HepG2.2.15细胞分泌HBsAg的影响[J]. 遵义医学院学报, 2009, 32(6): 559-561, 566.
[51] 艾力, 黄皓. 小柴胡汤合紫花地丁汤加减方治疗新型冠状病毒肺炎(2019-nCoV)轻中度患者疗效初探[J]. 湖北中医杂志, 2021, 43(2): 50-53.
[52] 翟建昭, 张苹, 张乃丹, 等. 自身免疫调节因子在机体免疫耐受中的作用机制研究进展[J]. 国际检验医学杂志, 2021, 42(15): 1894-1897.
[53] 施杨, 郭法利, 刘海泉. 紫花地丁提取物对三文鱼中副溶血性弧菌的抑制作用[J]. 山东农业大学学报(自然科学版), 2017, 48(2): 161-165.
[54] 李培锋, 贺春阳, 关红. 五种中药的免疫作用研究[J]. 内蒙古农牧学院学报, 1990, 11(2): 90-93.
[55] 刘湘新, 刘进辉, 刘自逵, 等. 紫花地丁的有效成分分析及抗菌作用研究[J]. 中兽医医药杂志, 2004, 23(3): 16-18.
[56] Zhang, T., Cang, W., Tian, L.M., et al. (2011) Experimental Study on the Inhibitory Effect of Viola yedoensis on U14 Tumor Bearing Mice. Shizhen Traditional Chinese Medicine Traditional Chinese Medicine, 22, 2926-2927.
[57] Zhang, F.J., Zhang, X., Niu, Y.B., et al. (2019) Study on the Anticancer Activity of Water Extract of Dandelion and Herb Viola. Northwestern Journal of Pharmacy, 34, 759-765.
[58] Yuan, H.C., Zhao, L.C., Wan, X.N., et al. (2020) Inhibitory Mechanism of Viola philippica Polysaccharide on A549 Cells. Journal of Tropical Medicine, 20, 1005-1008.
[59] 秦民坚, 洪俊丽, 朱婕, 等. 紫花地丁总酚提取物治疗高尿酸血症的用途[P]. 中国专利, CN102210787A, 2011-10-12.
[60] Zuo, J., He, H., Zuo, Z., Bou-Chacra, N. and Löbenberg, R. (2018) Erding Formula in Hyperuricaemia Treatment: Unfolding Traditional Chinese Herbal Compatibility Using Modern Pharmaceutical Approaches. Journal of Pharmacy and Pharmacology, 70, 124-132. [Google Scholar] [CrossRef] [PubMed]
[61] 杜文迪, 李国峰, 陈海芳, 等. 基于网络药理学探寻紫花地丁抗痛风/高尿酸血症的作用机制[J]. 中药材, 2021, 44(2): 428-435.