基于信号通路探讨中药方剂与单体干预冠心病机制的研究进展
Research Progress in Exploring the Mechanism of Intervention in Coronary Heart Disease by Chinese Herbal Formulae and Monomers Based on Signaling Pathways
DOI: 10.12677/hjmce.2025.133026, PDF,   
作者: 周春雷*, 项 杨, 秦溪悦, 潘柏宁：黑龙江中医药大学研究生院，黑龙江 哈尔滨；邹国良#：黑龙江中医药大学附属第一医院，黑龙江 哈尔滨
关键词: 冠心病；信号通路；中医药；药理机制；研究进展；Coronary Heart Disease； Signaling Pathway； Traditional Chinese Medicine； Pharmacological Mechanism； Research Progress
摘要: 冠心病是心肌提供含氧血液的血管发生狭窄，引起心肌缺血、缺氧，主要归因于冠状动脉粥样硬化。现阶段西医治疗冠心病的药物主要为抗心肌缺血类药物、抗血小板类药物，但这些药物在远期治疗过程中存在较多的不良反应。因此，冠心病高发病率和有效治疗策略的缺乏，促使着科学研究者从自然资源中发现新的药物。中医药治疗冠心病的有效性已被诸多学者挖掘，以其治疗通路广、作用靶点全、检验有效且不良反应小等优势造福广大患者。多项研究显示中药单体及复方可通过靶向多条信号通路保护心肌细胞，进而改善心功能。但目前对中医药调节冠心病相关信号通路的系统总结较少，故该综述通过检索近年来国内外相关文献资料，重点理清中医药治疗冠心病机制的关键信号通路，主要包括核因子E2相关因子-2 (Nrf2)信号通路、核转录因子-kB (NF-kB)信号通路、Janus酪氨酸蛋白激酶(JAK)信号通路、腺苷酸活化蛋白激酶(AMPK)信号通路等，以期加深对中医药抗冠心病功能的认识，为进一步的研究和冠心病的治疗提供参考。
Abstract: Coronary heart disease occurs when the blood vessels supplying oxygenated blood to the myocardium become narrowed, resulting in myocardial ischemia and hypoxia. The primary cause is coronary atherosclerosis. Currently, in Western medicine, the main treatments for coronary heart disease include anti-myocardial ischemia drugs and anti-platelet drugs. However, these medications also have numerous adverse reactions during long-term treatment. The efficacy of traditional Chinese medicine (TCM) in treating coronary heart disease has been explored by many scholars. It benefits a large number of patients with advantages such as wide treatment pathways, comprehensive action targets, simplicity, effectiveness, affordability, and low adverse reactions. Numerous studies have indicated that single TCM compounds and complex prescriptions can protect cardiomyocytes and improve cardiac function by regulating multiple signaling pathways related to the disease [such as the nuclear factor E2-related factor 2 (Nrf2) signaling pathway, the nuclear factor kappa B (NF-kB) signaling pathway, the Janus kinase (JAK) signaling pathway, the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway, and other signaling pathways]. Nevertheless, the relevant domestic research and literature are relatively scarce and incomplete at present. Further studies at the molecular biology level are required in the future to provide references for safer and more effective treatment of coronary heart disease.
文章引用：周春雷, 邹国良, 项杨, 秦溪悦, 潘柏宁. 基于信号通路探讨中药方剂与单体干预冠心病机制的研究进展[J]. 药物化学, 2025, 13(3): 247-257. https://doi.org/10.12677/hjmce.2025.133026

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