钆基MRI造影剂的合成研究进展
Research Progress on the Synthesis of Gadolinium-Based MRI Contrast Agents
DOI: 10.12677/hjmce.2026.141004, PDF,   
作者: 邓兴龙：浙江师范大学含氟新材料研究所，浙江 金华
关键词: 磁共振成像；钆；造影剂；合成；Magnetic Resonance Imaging； Gadolinium； Contrast Agent； Synthesis
摘要: 磁共振成像(MRI)是一种强大的诊断技术，它可以穿透组织深处，提供极好的空间分辨率，而钆元素由于其强顺磁性被广泛应用于增强磁共振成像的造影剂。然而，由于缺乏具有高弛豫性、靶向性、特异性的造影剂，面对复杂多变的病况，临床MRI诊断受到严重阻碍。同时，不稳定的造影剂释放出游离的钆离子会增加肾纤维化的风险。因此，开发具有安全性、靶向性、高效能的钆基造影剂成为当下医学影像技术的重大挑战。本文主要论述了关于钆基造影剂效果的影响因素以及部分化合物的合成研究。
Abstract: Magnetic Resonance Imaging (MRI) is a powerful diagnostic technique that can penetrate deep into tissues and provide excellent spatial resolution. Gadolinium, due to its strong paramagnetization, is widely used as a contrast agent to enhance MRI. However, due to the lack of contrast agents with high relaxation, targeting and specificity, clinical MRI diagnosis has been seriously hindered in the face of complex and changeable disease conditions. Meanwhile, unstable contrast agents release free gadolinium ions, which increase the risk of renal fibrosis. Therefore, developing gadolinium-based contrast agents that are safe, targeted and highly efficient has become a major challenge in current medical imaging technology. This article mainly discusses the influencing factors of the effect of gadolinium-based contrast agents and the synthesis research of some compounds.
文章引用：邓兴龙. 钆基MRI造影剂的合成研究进展[J]. 药物化学, 2026, 14(1): 27-38. https://doi.org/10.12677/hjmce.2026.141004

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